diff --git a/lib/vhost/vhost.c b/lib/vhost/vhost.c
index 8cd727ca2f..8bccdd8584 100644
--- a/lib/vhost/vhost.c
+++ b/lib/vhost/vhost.c
@@ -369,6 +369,7 @@ cleanup_device(struct virtio_net *dev, int destroy)
 
 static void
 vhost_free_async_mem(struct vhost_virtqueue *vq)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	if (!vq->async)
 		return;
@@ -393,7 +394,9 @@ free_vq(struct virtio_net *dev, struct vhost_virtqueue *vq)
 	else
 		rte_free(vq->shadow_used_split);
 
+	rte_spinlock_lock(&vq->access_lock);
 	vhost_free_async_mem(vq);
+	rte_spinlock_unlock(&vq->access_lock);
 	rte_free(vq->batch_copy_elems);
 	vhost_user_iotlb_destroy(vq);
 	rte_free(vq->log_cache);
@@ -1669,6 +1672,7 @@ rte_vhost_extern_callback_register(int vid,
 
 static __rte_always_inline int
 async_channel_register(struct virtio_net *dev, struct vhost_virtqueue *vq)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async;
 	int node = vq->numa_node;
diff --git a/lib/vhost/vhost.h b/lib/vhost/vhost.h
index 82fe9b5fda..c05313cf37 100644
--- a/lib/vhost/vhost.h
+++ b/lib/vhost/vhost.h
@@ -326,7 +326,7 @@ struct vhost_virtqueue {
 	struct rte_vhost_resubmit_info *resubmit_inflight;
 	uint64_t		global_counter;
 
-	struct vhost_async	*async;
+	struct vhost_async	*async __rte_guarded_var;
 
 	int			notif_enable;
 #define VIRTIO_UNINITIALIZED_NOTIF	(-1)
diff --git a/lib/vhost/vhost_user.c b/lib/vhost/vhost_user.c
index 70d221b9f6..8c1d60b76b 100644
--- a/lib/vhost/vhost_user.c
+++ b/lib/vhost/vhost_user.c
@@ -2168,6 +2168,7 @@ vhost_user_set_vring_enable(struct virtio_net **pdev,
 			int main_fd __rte_unused)
 {
 	struct virtio_net *dev = *pdev;
+	struct vhost_virtqueue *vq;
 	bool enable = !!ctx->msg.payload.state.num;
 	int index = (int)ctx->msg.payload.state.index;
 
@@ -2175,15 +2176,18 @@ vhost_user_set_vring_enable(struct virtio_net **pdev,
 		"set queue enable: %d to qp idx: %d\n",
 		enable, index);
 
-	if (enable && dev->virtqueue[index]->async) {
-		if (dev->virtqueue[index]->async->pkts_inflight_n) {
+	vq = dev->virtqueue[index];
+	/* vhost_user_lock_all_queue_pairs locked all qps */
+	vq_assert_lock(dev, vq);
+	if (enable && vq->async) {
+		if (vq->async->pkts_inflight_n) {
 			VHOST_LOG_CONFIG(dev->ifname, ERR,
 				"failed to enable vring. Inflight packets must be completed first\n");
 			return RTE_VHOST_MSG_RESULT_ERR;
 		}
 	}
 
-	dev->virtqueue[index]->enabled = enable;
+	vq->enabled = enable;
 
 	return RTE_VHOST_MSG_RESULT_OK;
 }
diff --git a/lib/vhost/virtio_net.c b/lib/vhost/virtio_net.c
index f2ab6dba15..6672caac49 100644
--- a/lib/vhost/virtio_net.c
+++ b/lib/vhost/virtio_net.c
@@ -102,6 +102,7 @@ static __rte_always_inline int64_t
 vhost_async_dma_transfer_one(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		int16_t dma_id, uint16_t vchan_id, uint16_t flag_idx,
 		struct vhost_iov_iter *pkt)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct async_dma_vchan_info *dma_info = &dma_copy_track[dma_id].vchans[vchan_id];
 	uint16_t ring_mask = dma_info->ring_mask;
@@ -151,6 +152,7 @@ static __rte_always_inline uint16_t
 vhost_async_dma_transfer(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		int16_t dma_id, uint16_t vchan_id, uint16_t head_idx,
 		struct vhost_iov_iter *pkts, uint16_t nr_pkts)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct async_dma_vchan_info *dma_info = &dma_copy_track[dma_id].vchans[vchan_id];
 	int64_t ret, nr_copies = 0;
@@ -434,6 +436,7 @@ static __rte_always_inline void
 vhost_async_shadow_enqueue_packed_batch(struct vhost_virtqueue *vq,
 				 uint64_t *lens,
 				 uint16_t *ids)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t i;
 	struct vhost_async *async = vq->async;
@@ -450,6 +453,7 @@ vhost_async_shadow_enqueue_packed_batch(struct vhost_virtqueue *vq,
 
 static __rte_always_inline void
 vhost_async_shadow_dequeue_packed_batch(struct vhost_virtqueue *vq, uint16_t *ids)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t i;
 	struct vhost_async *async = vq->async;
@@ -611,6 +615,7 @@ vhost_async_shadow_enqueue_packed(struct vhost_virtqueue *vq,
 				   uint16_t *id,
 				   uint16_t *count,
 				   uint16_t num_buffers)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t i;
 	struct vhost_async *async = vq->async;
@@ -1118,6 +1123,7 @@ static __rte_always_inline int
 async_fill_seg(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mbuf *m, uint32_t mbuf_offset,
 		uint64_t buf_iova, uint32_t cpy_len, bool to_desc)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 	uint64_t mapped_len;
@@ -1195,6 +1201,7 @@ static __rte_always_inline int
 mbuf_to_desc(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mbuf *m, struct buf_vector *buf_vec,
 		uint16_t nr_vec, uint16_t num_buffers, bool is_async)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t vec_idx = 0;
 	uint32_t mbuf_offset, mbuf_avail;
@@ -1323,6 +1330,7 @@ vhost_enqueue_single_packed(struct virtio_net *dev,
 			    struct rte_mbuf *pkt,
 			    struct buf_vector *buf_vec,
 			    uint16_t *nr_descs)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t nr_vec = 0;
 	uint16_t avail_idx = vq->last_avail_idx;
@@ -1383,6 +1391,7 @@ vhost_enqueue_single_packed(struct virtio_net *dev,
 static __rte_noinline uint32_t
 virtio_dev_rx_split(struct virtio_net *dev, struct vhost_virtqueue *vq,
 	struct rte_mbuf **pkts, uint32_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t pkt_idx = 0;
 	uint16_t num_buffers;
@@ -1610,6 +1619,7 @@ static __rte_always_inline int16_t
 virtio_dev_rx_single_packed(struct virtio_net *dev,
 			    struct vhost_virtqueue *vq,
 			    struct rte_mbuf *pkt)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct buf_vector buf_vec[BUF_VECTOR_MAX];
 	uint16_t nr_descs = 0;
@@ -1634,6 +1644,7 @@ virtio_dev_rx_packed(struct virtio_net *dev,
 		     struct vhost_virtqueue *__rte_restrict vq,
 		     struct rte_mbuf **__rte_restrict pkts,
 		     uint32_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t pkt_idx = 0;
 
@@ -1733,6 +1744,7 @@ rte_vhost_enqueue_burst(int vid, uint16_t queue_id,
 
 static __rte_always_inline uint16_t
 async_get_first_inflight_pkt_idx(struct vhost_virtqueue *vq)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 
@@ -1761,6 +1773,7 @@ store_dma_desc_info_split(struct vring_used_elem *s_ring, struct vring_used_elem
 static __rte_noinline uint32_t
 virtio_dev_rx_async_submit_split(struct virtio_net *dev, struct vhost_virtqueue *vq,
 	struct rte_mbuf **pkts, uint32_t count, int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct buf_vector buf_vec[BUF_VECTOR_MAX];
 	uint32_t pkt_idx = 0;
@@ -1867,6 +1880,7 @@ vhost_enqueue_async_packed(struct virtio_net *dev,
 			    struct buf_vector *buf_vec,
 			    uint16_t *nr_descs,
 			    uint16_t *nr_buffers)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t nr_vec = 0;
 	uint16_t avail_idx = vq->last_avail_idx;
@@ -1925,6 +1939,7 @@ vhost_enqueue_async_packed(struct virtio_net *dev,
 static __rte_always_inline int16_t
 virtio_dev_rx_async_packed(struct virtio_net *dev, struct vhost_virtqueue *vq,
 			    struct rte_mbuf *pkt, uint16_t *nr_descs, uint16_t *nr_buffers)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct buf_vector buf_vec[BUF_VECTOR_MAX];
 
@@ -1947,6 +1962,7 @@ virtio_dev_rx_async_packed_batch_enqueue(struct virtio_net *dev,
 			   struct rte_mbuf **pkts,
 			   uint64_t *desc_addrs,
 			   uint64_t *lens)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t buf_offset = sizeof(struct virtio_net_hdr_mrg_rxbuf);
 	struct virtio_net_hdr_mrg_rxbuf *hdrs[PACKED_BATCH_SIZE];
@@ -2007,6 +2023,7 @@ virtio_dev_rx_async_packed_batch(struct virtio_net *dev,
 			   struct vhost_virtqueue *vq,
 			   struct rte_mbuf **pkts,
 			   int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint64_t desc_addrs[PACKED_BATCH_SIZE];
 	uint64_t lens[PACKED_BATCH_SIZE];
@@ -2022,6 +2039,7 @@ virtio_dev_rx_async_packed_batch(struct virtio_net *dev,
 static __rte_always_inline void
 dma_error_handler_packed(struct vhost_virtqueue *vq, uint16_t slot_idx,
 			uint32_t nr_err, uint32_t *pkt_idx)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t descs_err = 0;
 	uint16_t buffers_err = 0;
@@ -2052,6 +2070,7 @@ dma_error_handler_packed(struct vhost_virtqueue *vq, uint16_t slot_idx,
 static __rte_noinline uint32_t
 virtio_dev_rx_async_submit_packed(struct virtio_net *dev, struct vhost_virtqueue *vq,
 	struct rte_mbuf **pkts, uint32_t count, int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t pkt_idx = 0;
 	uint16_t n_xfer;
@@ -2124,6 +2143,7 @@ virtio_dev_rx_async_submit_packed(struct virtio_net *dev, struct vhost_virtqueue
 
 static __rte_always_inline void
 write_back_completed_descs_split(struct vhost_virtqueue *vq, uint16_t n_descs)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 	uint16_t nr_left = n_descs;
@@ -2156,6 +2176,7 @@ write_back_completed_descs_split(struct vhost_virtqueue *vq, uint16_t n_descs)
 static __rte_always_inline void
 write_back_completed_descs_packed(struct vhost_virtqueue *vq,
 				uint16_t n_buffers)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 	uint16_t from = async->last_buffer_idx_packed;
@@ -2220,6 +2241,7 @@ write_back_completed_descs_packed(struct vhost_virtqueue *vq,
 static __rte_always_inline uint16_t
 vhost_poll_enqueue_completed(struct virtio_net *dev, struct vhost_virtqueue *vq,
 	struct rte_mbuf **pkts, uint16_t count, int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 	struct async_inflight_info *pkts_info = async->pkts_info;
@@ -2824,6 +2846,7 @@ desc_to_mbuf(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		  struct buf_vector *buf_vec, uint16_t nr_vec,
 		  struct rte_mbuf *m, struct rte_mempool *mbuf_pool,
 		  bool legacy_ol_flags, uint16_t slot_idx, bool is_async)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t buf_avail, buf_offset, buf_len;
 	uint64_t buf_addr, buf_iova;
@@ -3029,6 +3052,7 @@ static uint16_t
 virtio_dev_tx_split(struct virtio_net *dev, struct vhost_virtqueue *vq,
 	struct rte_mempool *mbuf_pool, struct rte_mbuf **pkts, uint16_t count,
 	bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t i;
 	uint16_t avail_entries;
@@ -3132,6 +3156,7 @@ static uint16_t
 virtio_dev_tx_split_legacy(struct virtio_net *dev,
 	struct vhost_virtqueue *vq, struct rte_mempool *mbuf_pool,
 	struct rte_mbuf **pkts, uint16_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_split(dev, vq, mbuf_pool, pkts, count, true);
 }
@@ -3141,6 +3166,7 @@ static uint16_t
 virtio_dev_tx_split_compliant(struct virtio_net *dev,
 	struct vhost_virtqueue *vq, struct rte_mempool *mbuf_pool,
 	struct rte_mbuf **pkts, uint16_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_split(dev, vq, mbuf_pool, pkts, count, false);
 }
@@ -3341,6 +3367,7 @@ vhost_dequeue_single_packed(struct virtio_net *dev,
 			    uint16_t *buf_id,
 			    uint16_t *desc_count,
 			    bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct buf_vector buf_vec[BUF_VECTOR_MAX];
 	uint32_t buf_len;
@@ -3389,6 +3416,7 @@ virtio_dev_tx_single_packed(struct virtio_net *dev,
 			    struct rte_mempool *mbuf_pool,
 			    struct rte_mbuf *pkts,
 			    bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 
 	uint16_t buf_id, desc_count = 0;
@@ -3419,6 +3447,7 @@ virtio_dev_tx_packed(struct virtio_net *dev,
 		     struct rte_mbuf **__rte_restrict pkts,
 		     uint32_t count,
 		     bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t pkt_idx = 0;
 
@@ -3462,6 +3491,7 @@ static uint16_t
 virtio_dev_tx_packed_legacy(struct virtio_net *dev,
 	struct vhost_virtqueue *__rte_restrict vq, struct rte_mempool *mbuf_pool,
 	struct rte_mbuf **__rte_restrict pkts, uint32_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_packed(dev, vq, mbuf_pool, pkts, count, true);
 }
@@ -3471,6 +3501,7 @@ static uint16_t
 virtio_dev_tx_packed_compliant(struct virtio_net *dev,
 	struct vhost_virtqueue *__rte_restrict vq, struct rte_mempool *mbuf_pool,
 	struct rte_mbuf **__rte_restrict pkts, uint32_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_packed(dev, vq, mbuf_pool, pkts, count, false);
 }
@@ -3588,6 +3619,7 @@ static __rte_always_inline uint16_t
 async_poll_dequeue_completed(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mbuf **pkts, uint16_t count, int16_t dma_id,
 		uint16_t vchan_id, bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t start_idx, from, i;
 	uint16_t nr_cpl_pkts = 0;
@@ -3634,6 +3666,7 @@ static __rte_always_inline uint16_t
 virtio_dev_tx_async_split(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mempool *mbuf_pool, struct rte_mbuf **pkts, uint16_t count,
 		int16_t dma_id, uint16_t vchan_id, bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	static bool allocerr_warned;
 	bool dropped = false;
@@ -3780,6 +3813,7 @@ virtio_dev_tx_async_split_legacy(struct virtio_net *dev,
 		struct vhost_virtqueue *vq, struct rte_mempool *mbuf_pool,
 		struct rte_mbuf **pkts, uint16_t count,
 		int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_async_split(dev, vq, mbuf_pool,
 				pkts, count, dma_id, vchan_id, true);
@@ -3791,6 +3825,7 @@ virtio_dev_tx_async_split_compliant(struct virtio_net *dev,
 		struct vhost_virtqueue *vq, struct rte_mempool *mbuf_pool,
 		struct rte_mbuf **pkts, uint16_t count,
 		int16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_async_split(dev, vq, mbuf_pool,
 				pkts, count, dma_id, vchan_id, false);
@@ -3799,6 +3834,7 @@ virtio_dev_tx_async_split_compliant(struct virtio_net *dev,
 static __rte_always_inline void
 vhost_async_shadow_dequeue_single_packed(struct vhost_virtqueue *vq,
 				uint16_t buf_id, uint16_t count)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	struct vhost_async *async = vq->async;
 	uint16_t idx = async->buffer_idx_packed;
@@ -3820,6 +3856,7 @@ virtio_dev_tx_async_single_packed(struct virtio_net *dev,
 			struct rte_mbuf *pkts,
 			uint16_t slot_idx,
 			bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	int err;
 	uint16_t buf_id, desc_count = 0;
@@ -3871,6 +3908,7 @@ virtio_dev_tx_async_packed_batch(struct virtio_net *dev,
 			   struct vhost_virtqueue *vq,
 			   struct rte_mbuf **pkts, uint16_t slot_idx,
 			   uint16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint16_t avail_idx = vq->last_avail_idx;
 	uint32_t buf_offset = sizeof(struct virtio_net_hdr_mrg_rxbuf);
@@ -3927,6 +3965,7 @@ static __rte_always_inline uint16_t
 virtio_dev_tx_async_packed(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mempool *mbuf_pool, struct rte_mbuf **pkts,
 		uint16_t count, uint16_t dma_id, uint16_t vchan_id, bool legacy_ol_flags)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	uint32_t pkt_idx = 0;
 	uint16_t slot_idx = 0;
@@ -4036,6 +4075,7 @@ static uint16_t
 virtio_dev_tx_async_packed_legacy(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mempool *mbuf_pool, struct rte_mbuf **pkts,
 		uint16_t count, uint16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_async_packed(dev, vq, mbuf_pool,
 				pkts, count, dma_id, vchan_id, true);
@@ -4046,6 +4086,7 @@ static uint16_t
 virtio_dev_tx_async_packed_compliant(struct virtio_net *dev, struct vhost_virtqueue *vq,
 		struct rte_mempool *mbuf_pool, struct rte_mbuf **pkts,
 		uint16_t count, uint16_t dma_id, uint16_t vchan_id)
+	__rte_exclusive_locks_required(&vq->access_lock)
 {
 	return virtio_dev_tx_async_packed(dev, vq, mbuf_pool,
 				pkts, count, dma_id, vchan_id, false);
